Aeglea BioTherapeutics Inc
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/*============================================= = Premarket Prep 06/01/21 = =============================================*/ U.S. stock futures looking higher, tracking gains in Europe and Asia ahead of manufacturing data that will give fresh insights into the economic recovery. S&P futures are looking higher after closing out May with its fourth consecutive monthly advance as investors have grown more confident that rising inflation won’t lead central banks to ease monetary policy measures, pushing major indexes back toward all-time highs in recent weeks. Economic data in the form of manufacturing showed strength in both Europe and Asia overnight with ISM data coming at 10:00 AM later this morning. For the week, the S&P rose 1.17%, the Dow added 0.94%, the Nasdaq gained 2.06%. For the month, the S&P rose 0.55%, the Dow added 1.94%, and the Nasdaq shed 1.53%. Stocks gained on Friday as investors considered new economic data on consumer spending, income and inflation alongside stronger-than-expected data reports from earlier this week. In Asian markets, The Nikkei Index fell -45 points to 28.814, the Shanghai Index rose 9 points to 3,624 and the Hang Seng Index jumped 316 points to 29,468. In Europe, the German DAX is up over 220 points to 15,640, while the FTSE 100 rises over 80 points to top 7,100. Market Closing Prices Yesterday The S&P 500 Index gained 3.23 points, or 0.08%, to 4,204.11 The Dow Jones Industrial Average rose 64.81 points, or 0.19%, to 34,529.45 The Nasdaq Composite climbed 12.46 points, or 0.09%, to 13,748.74 The Russell 2000 Index declined -4.10 points, or 0.18% to 2,268.97 Events Calendar for Today 7:45 AM ET ICSC Weekly Retail Sales 8:55 AM ET Johnson/Redbook Weekly Sales 9:45 AM EST Markit Manufacturing PMI, May-F 10:00 AM EST Construction Spending for April 10:00 AM EST ISM Manufacturing PMI, for May 10:30 AM EST Dallas Fed Manufacturing for May Earnings Calendar: Earnings Before the Open: $GHM, $KIRK Earnings After the Close: $AMBA, $APPS, $HPE, $ITI, $MDLA, $OESX, $ZM Other Key Events: Cowen 49th Annual TMT Conference (virtual), 6/1-6/3 Deutsche Bank FinTech and Info Service Conference (virtual), 6/1-6/2 Goldman Sachs 3rd Asia Spotlight Symposium (virtual), 6/1-6/4 Jefferies Global Healthcare Conference, 6/1-6/3 KeyBanc Capital Markets Industrials & Basic Materials Conference (virtual), 6/1-6/4 William Blair 40th Annual Growth Stock Conference (virtual), 6/1-6/3 OPEC+ June meeting Macro Up/Down Last Nymex 1.78 68.10 Brent 1.39 70.71 Gold 0.15 1,907.00 EUR/USD 0.0001 1.2228 JPY/USD 0.03 109.61 10-Year Note +0.028 1.622% World News China’s factory activity expanded at the fastest pace this year in May as domestic and export demand picked up, as the Caixin/Markit Manufacturing Purchasing Managers’ Index (PMI) rose to 52.0 last month, the highest level since December and inching up from April’s 51.9. China will allow all couples to have a third child, a surprise move aimed at slowing the nation’s declining birthrate as risks to the economy’s long-term prospects mount because of a rapidly aging population OECD releases U.S. economic forecasts in Paris as PCE 2.6% y/y in 2022; 2.9% y/y in 2021; core PCE 2.6% y/y in 2022; 2.5% y/y in 2021; unemployment rate 4.3% y/y in 2022; 5.6% y/y in 2021 Iran and world powers have started what could be their final negotiations to revive a 2015 nuclear accord that limited the Islamic Republic’s atomic activities in return for sanctions relief. The fifth round of talks has begun in Vienna RBA Rate Decision: Leaves cash rate unchanged at 0.1%, leaves 3Y AGB yield target at 0.1%; RBA won’t increase cash rate until actual inflation is sustainably within 2-3% target range which is unlikely to be 2024 at earliest; a pick-up in inflation/wages is expected but likely to be gradual & modest Sector News Breakdown Consumer AMC Entertainment ($AMC) issued to Mudrick Capital Management, 8.5 mln shares of company’s class a common stock for $230.5 mln Nio ($NIO) said it delivered 6,711 vehicles in May, up 95.3% Y/Y and down 5.5% M/M from April delivery of 7,102 vehicles. Xpeng Inc ($XPEV) said May deliveries jump nearly sixfold as May vehicle deliveries surged 483% to 5,686 units, spurred by record-high demand for XPEV’s P7 sedan Krispy Kreme has filed a Registration Statement on Form S-1 with the SEC relating to the proposed initial public offering of its common stock. The number of shares to be offered and the price range for the proposed offering have not yet been determined Macau’s gaming bureau reported May gross revenue from games of fortune in the region increased 492.2% year-over-year to 10.445B patacas (watch shares of $WYNN, $MLCO, $MGM) Planet Fitness ($PLNT) shares stock could drop 50% after a stunning recovery according to Barron’s as growth slows and the market becomes saturated. Article notes Teton Fund Management, which has shorted the stock, says millions of members will never return to a gym. Dollar General ($DG) and Dollar Tree ($DLTR) reported fiscal-first-quarter results before the bell on Thursday, and both beat analysts’ expectations-but that’s where the similarities end, according to Barron’s. DLTR warned freight costs could have a big impact on earnings, the latest indication that Dollar General is the stronger operator-and that doesn’t look set to change anytime soon For airlines, the Transportation Security Administration (TSA) reported that it screened almost 1.96 million people at airports, compared with 1.85 million on Thursday. That’s the most since March 7, 2020, when the COVID-19 pandemic was in its early stages Energy, Industrials and Materials Oil prices are higher by over 2% (WTI crude $68 per barrel and Brent tops $70) as the latest OPEC+ gathering takes place via videoconference today. OPEC+ decided in April to return 2.1M barrels per day to the market from May to July, anticipating rising global demand. Since the announcement, the crude price has risen from $60 toward the $70 level Exxon Mobil Corp ($XOM) rises along with Equinor EQNR and Petrogal Brasil says they will proceed with an $8 bln development of Brazil’s Bacalhau oil discovery Exxon ($XOM) suffered a setback this week when it lost at least two board seats to the upstart activist Engine No. 1, but the defeat could move the oil giant forward to benefit both the company and the shareholders, according to Barron’s Virgin Galactic ($SPCE) filed a shelf registration for $1 billion of mixed securities, plus 2.7m shares issuable upon the exercise of previously sold warrants Financials American Financial ($AFG) declares special dividend of $14 per share after announces closing of the sale of its annuity businesses and declares special dividend Healthcare Liminal BioSciences Inc. ($LMNL) said it has decided to stop its plans to move fezagepras into a Phase II clinical study in Idiopathic Pulmonary Fibrosis and a phase Ia/IIb study in Hypertriglyceridemia, as it evaluates the impact of the PK data profile observed in the on-going study. Forte Biosciences ($FBRX) files $300M mixed securities shelf Aeglea BioTherapeutics ($AGLE) files to sell 19.02M shares of common stock for holders Technology, Media & Telecom Cloudera ($CLDR) entered into a definitive agreement to be acquired by affiliates of Clayton, Dubilier & Rice and KKR ($KKR) in an all-cash transaction valued at approximately $5.3B (confirming reports overnight by the WSJ). Cloudera shareholders will receive $16.00 in cash per share, representing a 24% premium to the closing price as of May 28, 2021 – confirms overnight WSJ https://on.wsj.com/3uCAZ0g RingCentral ($RNG) team up with Deutsche Telekom ($DTEGY) to transform business communications for customers of all sizes. The chip shortage is creating an opportunity for two stocks according to Barron’s, Applied Materials ($AMAT) and Lam Research ($LRCX) saying both trade at about 20x earnings estimates for the next 12 months, lower than the multiples of S&P 500 Index and the PHLX semiconductor Index. SemiLEDs ($LEDS) files $30M mixed securities shelf
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Aeglea BioTherapeutics is a clinical-stage biotechnology company redefining the potential of human enzyme therapeutics to benefit people with rare and devastating metabolic diseases with limited treatment options. Aeglea's lead product candidate, pegzilarginase, is in a pivotal Phase 3 trial for the treatment of Arginase 1 Deficiency and has received both Rare Pediatric Disease and Breakthrough Therapy Designation. In the second quarter of 2020, the Company initiated a Phase 1/2 clinical trial of AGLE-177 for the treatment of Homocystinuria. AGLE-177 has also been granted Rare Pediatric Disease Designation. Aeglea has an active discovery platform focused on engineering small changes in human enzymes to have a big impact on the lives of patients and their families.