Bicycle Therapeutics Plc
15.23 - 62.08
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Wednesday, October 13, 2021 Futures Up/Down % Last Dow 34.00 0.10% 34,295 S&P 500 5.75 0.14% 4,346 Nasdaq 61.75 0.42% 14,715 U.S. futures recover from overnight losses ahead of Dow component JPMorgan earnings and inflation data later this morning (CPI), reversing overnight losses despite weakness in Dow component Apple (AAPL), which is down about -0.5% after reports it expects to make 10 million fewer iPhone than planned and is poised to slash iPhone production goal due to chip crunch. Oil prices and Treasury yields decline, while gold rises ahead of a key reading of consumer price September inflation. Futures are getting a boost after better economic data in China as September exports rose 28.1% from last year as consumer demand outpace supply chain disruptions and power shortages, while last night’s passage of a debt ceiling extension by House lawmakers puts at least one market concern to the side until early December. In Asian markets, The Nikkei Index fell -90 points to 28,140, the Shanghai Index rose 14 points to 3,561 and the Hang Seng Index was closed. In Europe, the German DAX is up over 100 points to 15,250, while the FTSE 100 is slightly lower at 7,120. U.S. stocks ended lower following a choppy session on Tuesday, with investors nervous about upcoming third-quarter earnings reports. In addition to the CPI data, the Federal Reserve will release minutes from its last policy meeting, and investors are looking for further clues on when the central bank could begin tapering its bond-buying program. Market Closing Prices Yesterday The S&P 500 Index dropped -10.54 points, or 0.24%, to 4,350.65 The Dow Jones Industrial Average fell -117.72 points, or 0.34%, to 34,378.34 The Nasdaq Composite slipped -20.28 points, or 0.14%, to 14,465.92 The Russell 2000 Index advanced 13.63 points, or 0.61% to 2,234.27 Events Calendar for Today 7:00 AM ET MBA Mortgage Applications Data 8:30 AM ET Consumer Price Index (CPI) Headline MoM for September…est. +0.3% 8:30 AM ET CPI Core: Ex Food & Energy MoM for September…est. +0.2% 8:30 AM ET Consumer Price Index (CPI) Headline YoY for September…est. +5.3% 8:30 AM ET CPI Core: Ex Food & Energy YoY for September…est.+4.0% 10:30 AM ET Weekly DOE Inventory Data 4:30 PM ET API Weekly Inventory Data Earnings Calendar: Earnings Before the Open: AYR, BLK, DAL, JPM, SOTK Earnings After the Close: ETWO, ODC Other Key Events: China CPI, PPO for September Macro Up/Down Last Nymex -0.56 80.08 Brent -0.60 82.82 Gold 11.60 1,772.80 EUR/USD 0.0034 1.1562 JPY/USD -0.04 113.56 10-Year Note -0.015 1.565% World News China September exports rose1% from last year as consumer demand outpace supply chain disruptions and power shortages Japanese Core Machine Orders (M/M) Aug: -2.4% (exp 1.4%; previous 0.9%); Core Machine Orders (Y/Y) Aug: 17.0% (exp 13.9%; previous 11.1%) The House on Tuesday voted along party lines to raise the U.S. borrowing limit into December, as Democratic lawmakers wrestled with how to set a new ceiling for U.S. debt later this year over Republican resistance. Sector News Breakdown Consumer Duckhorn Portfolio Inc ($NAPA) said selling stockholders are offering 12 mln shares of common stock Monster Beverage ($MNST) downgraded to Hold from Buy at Jefferies Energy, Industrials and Materials International Paper ($IP) announces up to $2B share repurchase program Boeing ($BA) is the latest federal contractor to mandate COVID-19 vaccinations for all employees by December 8 under the Biden administration’s new rules saying its 125K U.S. employees must show proof of vaccination or have an approved religious or medical exemption by the deadline. Yesterday, Chicago soybean futures fell to the lowest level in nearly a year following a U.S. Department of Agriculture report that showed larger than expected yields of soybeans and corn; the USDA showed an uptick of nearly 100M bushels to U.S. corn ending stocks Glencore Plc ($GLNCY) said that it had reached an agreement to sell its zinc business in Bolivia to Canada’s Santa Cruz Silver Mining for some $110M Rattler Midstream LP ($RTLR), a subsidiary of Diamondback Energy, Inc. (FANG) announces strategic midland basin gas gathering & processing joint venture; invested approximately $104 mln in cash to acquire a minority interest in joint venture Vistra ($VST) announces $2 billion share repurchase program Gran Tierra Energy Inc. ($GTE) said that Q3 production grew 53% and that it expects the gains to continue in Q4; said it has produced an average of 28,957 barrels of oil a day in the quarter, compared with 18,944 barrels a day in the prior year period and 23,035 barrels a day QoQ Greenbrier ($GBX) announced the acquisition of more than 3,600 railcars, a portion of which will be held in GBX Leasing Financials BlackRock ($BLK) Q3 adj EPS $10.95 vs. est. $9.35; Q3 revs $5.05B vs. est. $4.9B; qtrly long-term net inflows of $98 billion; assets under management at qtr-end were $9.46 trillion vs $7.81 trillion at end of Q3 AvidXchange ($AVDX)64M share IPO price $25.00 AllianceBernstein L.P. ($AB) preliminary assets under management decreased to $742 billion during September 2021 from $761B at the end of August. Firmwide net inflows were outweighed by market depreciation, resulting in a 2% decline in AUM. In the month of September, net inflows to Retail and Private Wealth were partially offset by net outflows from Institutions. Ellington Financial Inc ($EFC) commenced an underwritten public offering of 5 mln shares of common stock RenaissanceRe Holdings Ltd. ($RNR) estimates that losses from certain 2021 catastrophe events will have a net negative impact of approximately $725 million on the Company’s Q3 results of operations Manning & Napier ($MN) preliminary assets under management (AUM) of $22B for September, compared with $22.7B as of Aug.31. Healthcare Sarepta ($SRPT) announces $500M common stock offering and guiding Q3 revs about $166.9M vs. est. $172M; had approximately $1.6 bln in cash, cash equivalents and investments as of September 30, 2021 CRISPR Therapeutics ($CRSP) shares slipped after announcing updated results from the company’s early-stage trial of its CAR-T cell therapy CTX110 as two patients in the phase 1 trial experienced Grade 3 or higher infections, with one patient having HHV-6 encephalitis, and another developing pseudomonal sepsis that resolved in four days. CytoSorbents ($CTSO) receives full FDA investigational device exemption approval to begin U.S. star-d trial on apixaban and rivaroxaban removal by the DrugSorb-ATR™ antithrombotic removal system during urgent cardiothoracic surgery Homology Medicines ($FIXX) announced the pheEDIT Phase 1 clinical trial for HMI-103, a one-time, in vivo product candidate that utilizes a gene editing approach for phenylketonuria, or PKU, based on the investigational new drug application, or IND, clearance from the FDA Apollo EndoSurgery ($APEN)4M share Spot Secondary priced at $7.75 Bicycle Therapeutics ($BCYC)24M share Secondary priced at $54.00 Relay Therapeutics ($RLAY)21M share Secondary priced at $26.50 Biogen ($BIIB) announces results of a new analysis of immune response to the COVID-19 vaccine among people with multiple sclerosis (MS). Teva Pharmaceuticals Europe BV, a European affiliate of Teva ($TEVA) presents new analyses of the COBRA study, which concluded no evidence was found to suggest that infants were adversely affected by maternal exposure to glatiramer acetate (GA) during pregnancy and breastfeeding with use of COPAXONE Technology, Media & Telecom Apple ($AAPL) suppliers Broadcom ($AVGO), Texas Instruments ($TXN) struggling to deliver enough chips; Apple expects to make 10 million fewer iPhone than planned and is poised to slash iPhone production goal due to chip crunch – Bloomberg (watch shares of $AAPL suppliers including $CRUS, $QRVO, $STM, $AVGO, $SWKS) SAP AG ($SAP) raised its 2021 projections for non-IFRS cloud revenue at constant currencies to range from EUR9.4B to EUR9.6B, up from its earlier view of EUR9.3 billion and EUR9.5 billion; also boosts cloud and software revenue at constant currencies view to EUR23.8 billion to EUR24.2 billion from its earlier view of EUR23.6 billion to EUR24 billion. Qualcomm ($QCOM) announces new $10.0 billion stock repurchase authorization IAC Inc. ($IAC) reports September Angi Inc. total revenue up 18% from last year with Dotdash revenue up 25%, and its Search business revenue up 74% from last year and Emerging & Other revenue was up 33% from last year Vimeo Inc ($VMEO) total revenue for September 2021 up 33%; subscribers for September 2021 up 14%; ARPU for September 2021 up 16% Smart Global Holding ($SGH) Q4 adj EPS $2.16 vs. est. $1.60; Q4 revs $467.7M vs. est. $461.3M; sees Q1 adj EPS $1.80-$2.20 vs. est. $1.49; sees Q1 revenue $440M-$480M vs. est. $458.55M; GAAP gross margin of 25.2%, up 620 basis points versus the year ago quarter and non-GAAP gross margin of 26.4%, up 690 basis points versus the year ago quarter VOXX International ($VOXX) 2Q EPS $0.01 vs est. $0.07 on sales $143.1Mm vs est. $134.4Mm
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the BCYC? > @RohanG said: Cs Sold?
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Friday, October 1, 2021 Futures Up/Down % Last Dow -153.00 0.46% 33,843 S&P 500 -17.00 0.44% 4,307 Nasdaq -55.25 0.38% 14448, U.S. equity futures extended declines Friday, following the worst month for tech stocks since the peak of the pandemic, as investors enter the final quarter of the year focused on inflation, energy markets and the Federal Reserve. S&P 500 drops 4.8% in September, its first monthly loss since January and biggest one-month drop since start of pandemic and lowest closing price since July 19th. Overall, for the month, the S&P fell 4.8%, the Dow fell 4.3% and the Nasdaq fell 5.3%. For the quarter (Q3), the S&P 500 rose 0.2%, the Dow fell 1.9% and the Nasdaq fell 0.4% following the precipitous September decline. Late last night, U.S. House Democratic leaders have delayed a planned vote on a $1 trillion bipartisan infrastructure bill that had been set for Thursday, bowing to party progressives who had demanded action on a larger social policy bill first. However, on a positive note, the U.S. government shutdown appears to be averted for now as Congress voted to continue funding the government through Dec. 3, backing the earlier bill out of the Senate and President Biden signed the measure before funding was to run out at midnight. In Asian markets, The Nikkei Index declined -681 points (2.31%) to 28,771, the Shanghai Index was closed and the Hang Seng Index was also closed. In Europe, the German DAX is down about -115 points to 15,150, while the FTSE 100 falls 1% or -70 points to 7,015. Crypto currencies surging for a second straight day as Bitcoin rises over 7% to $46,600, while Ethereum rises over 6.5% at $3,175 in another spike across the board. Positive vaccine news overnight as Merck ($MRK) announced positive COVID-19 vaccine trial news. Market Closing Prices Yesterday The S&P 500 Index dropped -51.92 points, or 1,19%, to 4,307.54 The Dow Jones Industrial Average fell -546.80 points, or 1.59%, to 33,843.92 The Nasdaq Composite slumped -63.86 1.42 points, or 0.44%, to 14,448.58 The Russell 2000 Index declined -20.94 points, or 0.94% to 2,204.37 Events Calendar for Today 8:30 AM ET Personal Income MoM for Aug…est. +0.3% 8:30 AM ET Personal Spending MoM for Aug 8:30 AM ET PCE Price Index MoM for Aug 8:30 AM ET PCE Price Index YoY for Aug 8:30 AM ET Core PCE Price Index MoM for Aug…est. +0.2% 8:30 AM ET Core PCE Price Index YoY for Aug…est. +3.6% 9:45 AM ET Markit Manufacturing PMI for Sept-F 10:00 AM ET Construction Spending MoM for Aug…est. +0.3% 10:00 AM ET ISM Manufacturing Index for September…est. 59.6 10:00 AM ET University of Michigan Confidence, Sept-Final…est. 71.0 1:00 PM EST Baker Hughes Weekly rig count data Macro Up/Down Last Nymex -0.63 74.40 Brent -0.43 77.88 Gold -2.60 1,755.90 EUR/USD 0.0001 1.1582 JPY/USD -0.16 111.11 10-Year Note -0.036 1.491% World News S. House Democratic leaders have delayed a planned vote on a $1 trillion bipartisan infrastructure bill that had been set for Thursday, bowing to party progressives who had demanded action on a larger social policy bill first. House Majority Leader Steny Hoyer said in a statement the House is expected to finish work on the infrastructure bill on Friday. The Bank of Japan’s tankan survey released Friday shows signs that the recovery in the manufacturing sector will be hampered by supply shortages as the index measuring large manufacturers’ stocks of finished goods dropped to +3 in the September survey from +6 three months earlier. That marked the tightest level since 1989. Sector News Breakdown Consumer Lordstown Motors ($RIDE) said it plans to sell its auto factory in Ohio to contract assembler Foxconn Technology Group for a purchase price of $230 million. Additionally, Foxconn plans to invest $50 million into the Ohio-based startup through a purchase of common stock. Helbiz ($HLBZ) rises after the transportation and media co announces CEO Salvatore Palella purchased units of PIPE (private investment in public equity) offering; On Aug 9, Palella bought 200,000 units of PIPE offering, consisting of 200,000 shares of Class A common and warrants to buy additional 200,000 shares at $11.50 per share Keurig Dr Pepper (KDP) is said to plan up to $4B stock buyback Coty ($COTY) agrees to sell partial stake in Wella to KKR at a 50% valuation premium versus initial Wella sale in exchange for approximately half of the preferred Coty shares owned by KKR. Coty will continue to own 30.6% of Wella, with a $1.38b implied value for the retained stake Li Auto ($LI) delivered 7,094 Li ONEs in September 2021, up 102.5% Y/Y but fell 24.8% M/M from August’s shipments of 9,433 units; Q3 2021 deliveries rose 190% Y/Y and 42.9% Q/Q to 25,116 vehicles, exceeding recently revised guidance of ~24,500 units Nio ($NIO) delivered 10,628 vehicles in September 2021, an all-time high monthly record representing growth of 125.7% Y/Y and 80.7% M/M from August’s deliveries of 5,880 units; company shipped 24,439 vehicles Q3 2021, representing an increase of 100.2% Y/Y, exceeding the revised guidance of ~22,500 to 23,500 vehicles. Tesla ($TSLA) missed its deadline to deliver the Model X in Q3 2021, but a handful of units of the new electric SUVs were spotted in Fremont factory, Electrek reported. It gives some hope that deliveries might start soon https://bit.ly/2Y8L4ba XPeng ($XPEV) recorded its highest-ever monthly deliveries in September 2021 of 10,412 Smart EVs, representing an increase of 199% Y/Y and a 44% increase over last month; also achieved a quarterly record of 25,666 deliveries in Q3 2021, up 48% Q/Q and 199% over prior year Energy, Industrials and Materials ExxonMobil ($XOM) says gas prices to boost 3q earnings by about $700M; says oil prices to boost 3q earnings by about $400M; says downstream margins to boost earnings by $600M SunPower Corp. ($SPWR) will replace Cimarex Energy Co. ($XEC) in the S&P MidCap 400 index before trading begins on Oct. 5, according to S&P Dow Jones Indices. S&P 500 constituent Cabot Oil & Gas Corp. is acquiring Cimarex Energy in a deal that is expected to close on Oct. 1. PDC Energy Inc ($PDCE) said anticipated total production near bottom of previous range of 190,000 to 195,000 boe per day for full-year 2021; sees FY 2021 oil production of 60,000 to 63,000 barrels per day, below previous range of 64,000 to 66,000 barrels per day JPMorgan upgraded shares of Southwest Airlines ($LUV) to Overweight from Neutral and Spirit airlines ($SAVE) downgraded at JPMorgan while adjusting other price tgts in the space Financials Jefferies Financial ($JEF) Q3 EPS $1.50 vs. est. $0.99; Q3 revs $1.65B vs. est. $1.74B Healthcare Merck ($MRK) and Ridgeback Biotherapeutics announce results from their oral antiviral medicine molnupiravir (MK-4482, EIDD-2801) from Phase 3 MOVe-OUT trial in patients with mild-to-moderate COVID-19. STAT News notes that in the Merck study, a five-day course of the oral medicine was administered within five days of patients’ symptom onset; half of those patients had at least one risk factor associated with poor disease outcomes (shares of rival COVID-19 vaccine makers PFE, BNTX, MRNA falling on the news) Exscientia ($EXAI) has priced its upsized U.S. IPO of 13.85M ADSs (from ~13.1M ADSs), representing 13.85M ordinary shares at $22.00/ADS, for total gross proceeds of ~$304.7M. Bicycle Therapeutics ($BCYC) to present bt5528 interim phase i data at AACR-NCI-EORTC virtual international conference on molecular targets and cancer therapeutics Haemonetics ($HAE) said the FDA has approved a same-day discharge indication for its VASCADE MVP vascular closure system used in atrial fibrillation ablation. Rockwell Medical ($RMTI) files $200M mixed securities shelf Technology, Media & Telecom Five9 ($FIVN) announced that its $14.7B merger agreement with Zoom Video (ZM) has been terminated by mutual agreement. The agreement did not receive the requisite number of votes from Five9 shareholders to approve the merger with Zoom. Under the deal terms announced in July, Five9 shareholders would have received 0.5533 Zoom share for every Five9 share. Walt Disney ($DIS) and Scarlett Johansson have resolved their legal battle over her salary in the movie “Black Widow,” ending a two-month fight between the two parties AMC Entertainment ($AMC) said it exercised option to repurchase $35M of 15% cash / 17% payment-in-kind ($PIK) Toggle First Lien Secured Notes due 2026 Alibaba ($BABA) downgraded to Outperform from Strong Buy at Raymond James with a price target of $240, down from $300 saying while they remain positive on Alibaba long-term and believes valuation remains attractive, feels the recovery in shares could take longer given the recent slowing of ecommerce growth combined with continued regulatory actions across China
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Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycles, for diseases that are underserved by existing therapeutics. Bicycles are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycles attractive candidates for drug development. Bicycle's lead product candidate, BT1718, a Bicycle Toxin Conjugate (BTC) that targets MT1-MMP, is being investigated in an ongoing Phase I/IIa clinical trial in collaboration with the Centre for Drug Development of Cancer Research UK. Bicycle is also evaluating BT5528, a second-generation BTC targeting EphA2, in a company-sponsored Phase I/II trial. BT8009 is a BTC targeting Nectin-4, a well-validated tumor antigen, and is also currently being evaluated in a Company-sponsored Phase I/II trial. Bicycle is headquartered in Cambridge, UK with many key functions and members of its leadership team located in Lexington, MA.
CEO: Kevin Lee
HQ: Babraham Hall Cambridge, CB22 3AT Cambridgeshire