$ETTX

Entasis Therapeutics Holdings Inc

  • NASDAQ
  • Health Technology
  • Biotechnology
  • Manufacturing
  • Pharmaceutical Preparation Manufacturing

PRICE

$2.2 ▲0.457%

Extented Hours

VOLUME

68,834

DAY RANGE

2.19 - 2.2

52 WEEK

0 - 2.2

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Tuesday, October 19, 2021 Futures Up/Down % Last Dow 125.00 0.34% 35,254 S&P 500 2o.25 0.45% 4,497 Nasdaq 52.50 0.34% 15,343 U.S. stock markets are looking to open higher, extending the winning streak for the S&P 500 to 5-days ahead of a busy morning of quarterly earnings, including vaccine maker and Dow component Johnson & Johnson (JNJ) and Procter & Gamble (PG). A modest pullback in 10-year Treasury note yields, which traded at 1.584% overnight, and a weaker U.S. dollar are also providing early support Tuesday. Oil prices look to extend gains, with WTI crude and Brent pushing higher. In Asian markets overnight, The Nikkei Index jumped 190 points to 29,215, the Shanghai Index rose 25 points to 3,593, and the Hang Seng Index climbed 377 points (1.49%) to 25, 787. In Europe, the German DAX is up a few points to trade just under 15,500, while the FTSE 100 also edges higher above the 7,200 level. U.S. stocks finished higher on Monday as investors prepare for strong earnings this week with 72 of the S&P 500 expected to report this week while overlooking worries over inflation, supply-chain issues and energy supply as oil prices closed higher again. Data Sunday night showed growth in China slowed to 4.9% for 3Q, hurt by a crackdown on tech, and real estate as well as power-shortage and supply-chain problems. Heavy weight tech stocks helped paced gains again on Monday ahead of key earnings from Netflix tonight and Tesla, Intel later this week. Small cap stocks, banks and energy were among underperformers as the Dow Jones Industrial Average finished Monday lower. Market Closing Prices Yesterday The S&P 500 Index gained 15.09 points, or 0.34%, to 4,486.46 The Dow Jones Industrial Average fell -36.15 points, or 0.10%, to 35,258.61 The Nasdaq Composite spiked 124.47 points, or 0.84%, to 15,021.81 The Russell 2000 Index advanced 2.19 points, or 0.10% to 2,267.84 Events Calendar for Today 7:45 AM ET ICSC Weekly Retail Sales 8:30 AM ET Housing Starts MoM for September 8:30 AM ET Building Permits MoM for September 8:55 AM ET Johnson/Redbook Weekly Sales 4:30 PM ET API Weekly Inventory Data Earnings Calendar: Earnings Before the Open: BK, CBSH, DOV, FITB, FMBI, HAL, IRDM, JNJ, KSU, MAN, MRTN, ONB, PG, PM, SBNY, SI, SNV, SYF, TRV Earnings After the Close: EQBK, FULT, IBKR, ISRG, LRN, NFLX, OMC, PZN, SMBK, UAL, UCBI, WDFC, WTFC Other Key Events: Google ($GOOGL) announced a virtual event for October 19th at 1PM ET / 10AM PT, officially introducing the Pixel 6 and Pixel 6 Pro The European Society of Gene and Cell Therapy (ESGCT) Congress 2021 is taking place virtually this year from October 19-22 Needham Virtual Global Access Inaugural Needham Biotech Private Company Virtual 1×1 Forum, 10/19-10/20 Macro Up/Down Last Nymex 0.99 83.43 Brent 0.53 84.86 Gold 14.10 1,781.70 EUR/USD 0.0055 1.1663 JPY/USD -0.21 114.09 10-Year Note +0.008 1.592% World News Senate Democrats on Tuesday will unveil a scaled-back version of a Biden administration proposal to crack down on wealthy tax cheats after conservative groups and the bank industry raised major privacy concerns, three people with knowledge of the coming announcement said, the Washington Post reported. Initially, the Department of Treasury and Senate Democrats had proposed requiring financial institutions to provide the Internal Revenue Service with additional information on bank accounts with more than $600 in annual deposits or withdrawals RBA Minutes of Oct Meeting: Reiterates they won’t hike rates until CPI is stably in 2-3% target band, central estimate is that economy will return to growth in Dec Qtr of this year & to pre Delta path in H2 2022, Delta interrupted Australian economic recovery, less accommodative policy would all else equal , see lower housing prices/credit growth but would also result in fewer jobs & lower wages Sector News Breakdown Consumer Tupperware Brands Corporation ($TUP) announces the entry into a definitive agreement for the sale of its House of Fuller beauty business in Mexico Energy, Industrials and Materials Halliburton ($HAL) Q3 adj EPS $0.28 vs. est. $0.28 on revs $3.86B vs. est. $3.9B Hexcel Corp. ($HXL) Q3 adj EPS $0.13 vs. est. $0.08; Q3 sales rise 16% YoY to $333.8M vs. est. $348.7M; commercial aerospace sales rise 30% YoY to $167.2M, space & defense sales up 1.5% YoY to $110.4M and industrial sales rise 14% YoY to $56.2M Steel Dynamics ($STLD) Q3 adj EPS $4.96 vs. est. $4.57; Q3 revs $5.1B vs. est. $4.98B; believe shipments could be in range of 2.0 mln tons to 2.2 mln tons in 2022; Record steel and steel fabrication operating income of $1.4 billion and $89 million, respectively; record cash flow from operations of $631 million and record adjusted EBITDA of $1.4 billion TechnipFMC ($FTI) and Talos Energy ($TALO) announced that they have entered into a long-term strategic alliance to develop and deliver technical and commercial solutions to Carbon Capture and Storage projects along the United States Gulf Coast AgEagle Aerial Systems ($UAVS) entered into a definitive agreement to buy Sensefly from Parrot at a valuation of $23M in cash and stock Financials Crypto stocks ($COIN, $MARA, $RIOT, $MSTR) in the spotlight as Bitcoin continued its climb toward all-time highs (last above $62K), bolstered by optimism over the launch of the first Bitcoin futures exchange-traded fund in the U.S. on Tuesday Silvergate Capital ($SI) Q3 EPS $0.88 vs. est. $0.71; did not record a provision for loan losses for the Q3, Q2 or Q3 of FY20 as a result of management’s assessment of the level of the allowance for loan losses, and the amount and mix of the loan portfolio, among other factors; book value per common share was $33.10, compared to $32.84 at June 30, and $15.18 at September 30, 2020 Bank of New York ($BK) Q3 EPS $1.04 vs. est. $0.99; Q3 revs $4.0B vs. est. $3.95B; qtrly total noninterest expense of $2.9 billion, increased 9%; at qtr end, aum of $2.3 trillion, increased 13%; qtrly total fee and other revenue of $3.39 bln vs $3.14 bln; qtrly asset servicing fees $1.22 bln vs $1.17 bln Commerce Bancshares ($CBSH) q3 eps $1.05 vs. Est. $0.99, q3 revenue $351.54m vs. Est. $349.85m Fifth Third ($FITB) Q3 EPS $0.97 vs. est. $0.91; raises dividend by 11%; Q3 NII $1.19B vs. $1.17B Synovus ($SNV) Q3 adj EPS $1.20 vs. est. $1.08; Q3 net charge-off ratio declined 6 bps from prior quarter to 0.22%; the non-performing loan and asset ratios each fell 1 bp to 0.41% and 0.45%, respectively; and criticized and classified loans declined 22% Credit Suisse ($CS) is in discussions with the U.S. government to settle a criminal investigation regarding the bank’s role in a $42B Mozambique bond scandal – Bloomberg Berkshire Hills Bancorp, Inc. ($BHLB) has entered into a partnership with Upstart (UPST), a leading artificial intelligence (AI) lending platform designed to improve access to affordable credit while reducing the risk and costs of lending. Equity LifeStyle Property ($ELS) 3Q adj FFO/share $0.65 vs. est. $0.62 on revs $332.9Mm vs est. $171.1Mm EverQuote ($EVER) guides 3Q revs $106.5-107.5Mm vs est. $110.2Mm; sees 3Q net loss $6.0-5.5Mm vs est. net loss $4.7Mm; plans to implement approx 10% structure reduction in non-marketing op exp FB Financial ($FBK) 3Q adj EPS $0.89 vs est. $0.81, NII on tax-equivalent basis $89.2Mm vs est. $88.5Mm PacWest Bancorp ($PACW) 3Q EPS $1.17 vs est. $1.03; NII $279.8Mm vs est. $278.4Mm ServisFirst Bancshares, Inc. ($SFBS) Q3 EPS $0.96, in-line with estimates; Total loans grew $163.1 million, or 8% annualized, during the quarter, while loans, excluding the impact of Paycheck Protection Program (“PPP”) loan forgiveness, grew $370.4 million, or 18% annualized; Book value per share increased to $20.56, a 17% increase year-over-year Zions Bancorp ($ZION) Q3 EPS $1.45 vs. est. $1.33; loan growth excluding PPP loans, was 5.6% on an annualized basis; reported continued strong deposit growth at an annualized pace of 9.3%; announced $46 million reversal of loss reserves into income (compared to positive +$55 mln); qtrly net interest income remained stable at $555 million Healthcare Johnson & Johnson ($JNJ) Q3 adj EPS $2.60 vs. est. $2.35; Q3 revs $23.34B vs. est. $23.72B; maintained its 2021 sales forecast for its COVID-19 vaccine at $2.5 billion and reported $502 million in sales of the single-dose shot in Q3; raises FY21 adjusted EPS view to $9.65-$9.70 from $9.50-$9.60 and boosts FY21 revenue view to $94.1B-$94.6B from $93.8B-$94.6B (est. $94.3B) Sage Therapeutics ($SAGE) and Biogen ($BIIB) announce plans to submit a new drug application (NDA) for Zuranolone to the U.S. FDA in the second half of 2022 with rolling submission expected to start in early 2022 Following the pre-NDA meeting, the companies confirmed the current efficacy and safety databases are expected to be adequate for filing with confirmed pathways for MDD and PPD. The planned initial submission package will be for the treatment of MDD with an anticipated PPD filing thereafter The FDA intends to allow Americans to get a different COVID-19 vaccine as a booster from the one that originally had, The New York Times’ reported, which could reduce the appeal of Johnson & Johnson ($JNJ) vaccine and provide flexibility to doctors and other vaccinators The U.S. FDA has approved Reddy’s Laboratories’ ($RDY) generic version of Bristol-Myers Squibb’s ($BMY) multiple myeloma treatment Revlimid (lenalidomide) capsules. Calithera Biosciences ($CALA) is acquiring two clinical-stage compounds from Takeda Pharmaceutical (TAK) to bolster its precision oncology pipeline in a cash and stock deal; Calithera will pay $10M upfront cash and $35M in Calithera Series A preferred stock. Entasis Therapeutics ($ETTX) announces positive topline results for sulbactam-durlobactam (SUL-DUR) from Phase 3 ATTACK trial; SUL-DUR first to achieve statistical non-inferiority in 28-day all-cause mortality in carbapenem-resistant Acinetobacter ($CRAB) patients; Statistically significant difference in clinical cure at Test of Cure vs. colistin; targeting NDA submission in mid-2022 Paratek Pharmaceuticals ($PRTK) announces enrollment of first patient in phase 2b study evaluating Nuzyra® (omadacycline) for nontuberculous mycobacterial pulmonary disease caused by mycobacterium abscesses complex Technology, Media & Telecom Micron ($MU): Commodity DRAM prices likely to fall 15-20% in 1Q22. Following peak shipments in the second and third quarters, the memory sector has entered a period of correction in the fourth quarter of 2021 that may last for 1-2 quarters, and commodity DRAM prices, in particular, will face higher downward pressure – Digitimes.com https://bit.ly/3G2l5D5

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/*============================================= = Monday, June 14, 2021 = =============================================*/ Futures Up/Down % Last Dow 13.00 0.04% 34,370 S&P 500 4.50 0.11% 4,241 Nasdaq 45.75 0.33% 14,031 U.S. stocks futures are looking higher, as the S&P 500 looks to build on last week’s new all-time highs as investors and markets prepare for the Federal Reserve monetary policy meeting later this week. The S&P 500 posted its second consecutive record closing high on Friday with investors assessing the Federal Reserve’s stance that inflation spikes will prove to be transitory. For the week, the Dow fell 0.8%, the S&P 500 ticked up 0.4%, and the Nasdaq jumped 1.8%. Looking ahead this week, the big focus remains the Federal Reserve’s June policy decision and press conference Wednesday afternoon hoping to clarify the path forward for monetary policy as investors contemplate the staying power of higher inflation. Currently, the Federal Reserve is conducting these purchases at a rate of $120 billion per month, with this quantitative easing having served as a key tool the Fed used to provide support and liquidity to the economy during the pandemic. A number of key economic data releases are also scheduled for this week, including May retail sales. The yield on the benchmark 10-year Treasury inched up to around 1.464% after hitting a three-month low last Thursday In Asian markets, The Nikkei Index rose 213 points to 29,161, the Shanghai Index was closed the Hang Seng Index was also closed. In Europe, the German DAX rises over 35 points to 15,730, while the FTSE 100 gains 30 points to 7,170. Crypto assets are looking higher to start the week after Tesla (TSLA) tweeted about Bitcoin: This is inaccurate. Tesla only sold ~10% of holdings to confirm BTC could be liquidated easily without moving market. When there’s confirmation of reasonable (~50%) clean energy usage by miners with positive future trend, Tesla will resume allowing Bitcoin transactions. Oil prices are higher and gold prices are markedly lower. Market Closing Prices Yesterday The S&P 500 Index climbed 8.26 points, or 0.19%, to 4,247.44 The Dow Jones Industrial Average rose 13.40 points, or 0.04%, to 34,479.60 The Nasdaq Composite jumped 49.12 points, or 0.35%, to 14,069.42 The Russell 2000 Index advanced 24.40 points, or 1.06% to 2,335.81 Events Calendar for Today No Major U.S. Economic Data Earnings Calendar: Earnings Before the Open: MPAA Earnings After the Close: ELTP, MMMB, RFIL Other Key Events: Citigroup European Healthcare Conference (virtual), 6/14-6/16 European Hematology Association (EHA) Virtual Meeting, 6/9-6/17 FBN Securities Valley tech Tour (virtual), 6/14-6/15 Macro Up/Down Last Nymex 0.57 71.48 Brent 0.67 73.36 Gold -20.85 1,856.65 EUR/USD 0.0004 1.2113 JPY/USD 0.04 109.70 10-Year Note +0.002 1.464% World News G7 will donate 1 bln doses by next year, leaders agreed to language condemning Russia for destabilizing behavior, called on China to respect human rights and fundamental freedoms, will carry on talks on recent finance ministers agreement on tax NATO leaders are expected to brand China a security risk to the Western alliance on Monday, a day after the Group of Seven rich nations issued a statement on human rights in China and Taiwan that Beijing said slandered its reputation. With allied leaders also raising concerns about Russia’s recent military build-up near Ukraine, NATO Secretary-General Jens Stoltenberg described the summit, the first Joe Biden will attend as U.S. president, as a “pivotal moment” – Reuters Sector News Breakdown Consumer Tesla Inc ($TSLA) CEO Elon Musk tweeted on Sunday that the electric car marker will resume allowing bitcoin transactions when miners who verify transactions use more renewable energy. “When there’s confirmation of reasonable (~50%) clean energy usage by miners with positive future trend, Tesla will resume allowing Bitcoin transactions,” he said in a tweet. Energy, Industrials and Materials Royal Dutch Shell (RDS/A) is reviewing its holdings in the largest U.S. oil field for a potential sale, people familiar with the matter told Reuters. The sale could be for part or all of Shell’s position in the U.S. Permian Basin, which accounted for around 6% of the Anglo-Dutch company’s total oil and gas output last year. The holdings could be worth more than $10 billion Petrobras ($PBR) says it plans to sell its remaining 37.5% stake in fuel distributor BR Distribuidora in a follow-on public offering Lumber futures posted their biggest-ever weekly loss, extending a tumble from all-time highs reached last month as sawmills ramp up output and buyers hold off on purchases. Prices fell 18% this week, and has now dropped almost 40% from the record high reached on May 10 Iran said it has reached a broad agreement with the U.S. over the lifting of sanctions on its industrial sectors, including energy, but warned there was “very little time left” for world powers to revive a 2015 nuclear deal Financials Equinix Inc ($EQIX) said it signed agreements for additional joint ventures with Singapore’s sovereign wealth fund GIC to add $3.9 billion to expand a data center program. As per the terms, GIC will own an 80% equity interest in future joint ventures, and Equinix will hold the remaining 20% equity interest. Washington Prime Group ($WPG) announced that it and certain of its subsidiaries have filed voluntary petitions for relief under Chapter 11 of the United States Bankruptcy Code Healthcare Novavax ($NVAX) rises after reporting ate-stage trial data showing its COVID-19 vaccine candidate is more than 90% effective against a variety of variants of the virus as the study puts NVAX on track for filing for U.S. emergency authorization. Novavax on Friday said its vaccine candidate, NVX-CoV2373, showed immune response and protection against the highly contagious coronavirus variant originally identified in South Africa Crispr Therapeutics ($CRSP) upgraded to Neutral from Sell with a price target of $132 up from $55 at Citigroup Cano Health ($CANO) has acquired University Health Care and its affiliates for $600M, with $540M in cash and $60M in equity. Entasis Therapeutics ($ETTX) revealed in an SEC filing its biggest shareholder Innoviva Inc. ($INVA) acquired ~6.27 mln shares at an avg price of $2 per share for total amount of ~$12.54M Alzheimer industry talked about in Barron’s saying Eli Lilly’s ($LLY) donanemab is one contender with Biogen’s ($BIIB) recently approved drug this week. Gantenerumab, from Roche Holding ($RHHBY), is another. Biogen and Japan’s Eisai ($ESALY), have a third, known as BAN2401. The European Medicines Agency ($EMA) has detected a rare new side effect called capillary leak syndrome following the vaccination with the COVID-19 vaccine developed by AstraZeneca ($AZN), known as Vaxzevria in the region. Technology, Media & Telecom Alphabet Inc’s ($GOOGL) has unveiled an option for small businesses to upgrade their Gmail accounts for greater calendaring, video chat and email newsletter functionalities. Google Workspace Individua starts at $7.99 monthly and includes a temporary $2 discount Qualcomm ($QCOM) said it would be willing to invest in ARM Holdings if Nvidia’s ($NVDA) planned $40B acquisition of the Softbank-owned chipmaker isn’t able to be completed due to antitrust concerns. Barron’s noted the shortage of semiconductors has given investors a new appreciation of their importance. Taiwan Semiconductor Manufacturing (TSM) sits at the nexus of the global chip renaissance. TSMC shares are down 15% since mid-February but investors should avoid the temptation to buy the dip — for now.

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47.85 M

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Company Information

Entasis is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel antibacterial products to treat serious infections caused by multidrug-resistant Gram-negative bacteria. Entasis' pathogen-targeted design platform has produced a pipeline of product candidates, including sulbactam-durlobactam (targeting Acinetobacter baumannii infections), zoliflodacin (targeting Neisseria gonorrhoeae infections), ETX0282CPDP (targeting Enterobacteriaceae infections) and ETX0462 (targeting Pseudomonas infections).

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