$MRTX

Healthcare Alkermes ($ALKS) announced that it received notices of partial termination in respect of two license agreements with Janssen Pharmaceutica N.V., a subsidiary of Johnson & Johnson Acadia Pharmaceuticals Inc ($ACAD) 3Q EPS ($0.09) vs est. ($0.26) on sales $131.6Mm vs est. $127.8Mm, says narrows FY Nuplazid sales guide to $480-500Mm Castle Biosciences ($CSTL) 3Q EPS ($0.47) vs est. ($0.41) on revs $23.5Mm vs est. $23Mm; says on track to achieve FY total revs guide of $89-93Mm vs est. $91.9Mm Clover Health ($CLOV) Q3 revs $427.2M vs est. $413.1M, adj EBITDA ($102.3M) vs est. ($99.5M); sees FY revs $1.42B-$1.47B vs est. $1.44B Curaleaf holdings ($CURLF) Q3 revenue $317M vs est. $328.3M, adj EBITDA $71M vs est. $92.1M; remains on track to generate revenue within lower end of $1.2B-$1.3B annual guidance range; said the acquisition of Tryke Companies reported earlier today bolsters its position in NV, AZ, UT and will be immediately accretive to margins and cash flow Fluidigm Corp ($FLDM) 3Q EPS ($0.18) vs est. ($0.22) on revs $28.5Mm vs est. $30Mm; says undertaking review of various options including with regard to strategic alternatives Invitae Corporation ($NVTA) Q3 adj EPS ($0.81) vs est. ($0.71) on revenue $114.4M vs est. $126.5M driven by billable volume 296k (+89% YoY); now sees FY revenue $450M-$475M, from $475M-$500M and below est. $484.5M Mirati Therapeutics, Inc. ($MRTX) 3Q EPS ($1.55) vs est. ($2.89) on revs $71.8Mm Nevro Corp. ($NVRO) Q3 EPS loss ($1.44) vs. est. loss (-$0.87); Q3 rev $93.2M vs. est. $91.59M; sees Q4 revs $94M-$98M Oak Street Health, Inc. ($OSH) Q3 EPS loss (-$0.49) vs. est. loss (-$0.42); Q3 revs $388.7M vs. est. $356.7M; The Company cared for approximately 100,500 risk-based patients, representing 76% of its total patients; adjusted EBITDA was $(64.3M), compared to $(22.8M) YoY SI-BONE ($SIBN) Q3 EPS ($0.48) vs est. ($0.42) on revenue $22.3M vs est. $22.5M, lowered FY21 revenue view to $89M-$90M from $92M-$94M (vs est. $92.7M) as uncertainty surrounding Covid-19’s impact on elective procedures and healthcare infrastructure remains Shockwave Medical ($SWAV) Q3 EPS $0.05 vs. est. loss (-$0.06); Q3 revs $65.2M vs. est. $61.2M; sees FY21 revenue $227M-$228M vs. est. $223.43M, which represents 235% to 236% growth YoY SmileDirectClub, Inc. ($SDC) shares fall -23%; 3Q EPS ($0.23) vs est. ($0.13) on revs $138Mm vs est. $$181Mm; guides FY revs $630-650Mm vs est. $757Mm Tactile Systems ($TCMD) shares fell -12%; 3Q EPS ($0.17) vs est. $0.12 on revs $52.5Mm vs est. $57.4Mm; sees FY revs +9-10% or $203.5M-$206M from $216.3M-$224.5M, below est. +18.7% Merck ($MRK) said the U.S. government will buy 1.4 million additional courses of their COVID-19 pill, molnupiravir, for about $1 bln and that the U.S. has now committed to purchase a total of about 3.1 million courses of molnupiravir for about $2.2 billion Haemonetics ($HAE) Q2 adj EPS $0.60 vs. est. $0.61; Q2 revs $239.9M vs. est. $241.4M; lowers FY22 adj EPS view to $2.40-$2.65 from $2.60-$3.00 and narrows its FY22 revenue view to up 13%-17% from up 13%-18% Technology, Media & Telecom Bandwidth Inc. ($BAND) Q3 adj EPS $0.25 vs. est. $0.08; Q3 revs $130.6M vs. est. $125.3M; guides Q4 EPS loss (15c-11c) vs. est. loss (-$0.01); sees Q4 revs $115.7M-$120.7M vs. est. $125.5M 3D Systems ($DDD) 3Q adj EPS $0.08 vs est. $0.05 on revs $156.1Mm vs est. $144.8Mm; guides FY adj gr mgn 41-43% vs est. 42.7% Five9 Inc. ($FIVN) 3Q adj EPS $0.28 vs est. $0.23 on revs $154.3Mm vs est. $146.8Mm; guides 4Q revs $164.5-165.5mm vs est. $157.8Mm, sees 4Q adj EPS $0.36-0.37 vs est. $0.34; sees FY revs $$600.5-601.5Mm vs est. $585.2Mm and adj EPS $1.09-1.10 vs est. $1.02 Instructure Holdings, Inc. ($INST) 3Q EPS ($0.10) vs est. $0.14 on revs $107.2Mm vs est. $101.1Mm; sees 4Q revs $106.9-107.9Mm vs est. $104.1Mm; guides FY revs $401.7-402.7Mm vs est. $397.4Mm, sees FY adj EBITDA $143.6-144.6Mm vs est. $130Mm Luminar Technologies, Inc. ($LAZR) shares rise 50%; said at the NVIDIA GTC conference that its lidar solution has been selected to be part of the sensor suite in the NVIDIA DRIVE Hyperion autonomous vehicle reference platform. This AI vehicle computing platform accelerates development of autonomous consumer vehicles with planned production starting in 2024. New Relic ($NEWR) Q2 adj EPS loss (10c) vs. est. loss (13c); Q2 revs $196M vss. Est. $182.21M; cuts FY22 adj EPS loss view to (60c)-(54c) from (52c)-(49c) while boosts FY22 revenue view to $778M-$782M from $730M-$735M (est. $736.8M) National CineMedia ($NCMI) Q3 EPS loss (19c) vs. est. loss (13c); Q3 revs $31.7M vs. est. $41.24M; Q3 adjusted OIBDA improved to negative $8.2 million for the third quarter of 2021 from negative $11.2 million for the third quarter of 2020 Roblox ($RBLX) shares rise 29%; Q3 EPS (13c) vs est. (14c) on bookings $637.8M vs est. $636.5M, revenue $509.5M, avg DAUs 47.3M vs est. 46.6M, hours engaged 11.2B (+28% YoY), avg booking per DAU $13.49 Sanmina ($SANM) Q4 adj EPS $0.95 vs. est. $0.99; Q4 revs $1.64B vs. est. $1.7B; sees Q1 adj EPS 90c-$1.00 vs. est. $1.01; sees Q1 revs $1.6B-$1.7B below consensus $1.76B Square Space ($SQSP) Q3 EPS 4c vs est. 14c on revenue $201M vs est. $205.2M; sees Q4 revenue $203M-$206M vs est. $205.2M, raised annual revenue forecast to $780M-$783M from $772M-$780M (est. $778.4M) and unlevered FCF to $117M-$122M from $102M-$116M TripAdvisor ($TRIP) 3Q adj EPS $0.16 vs est. $0.24 on revs $303Mm vs est. $304.4Mm; avg monthly unique users on branded websites rose to about 76% of 2019 comparable period; says CEO will step down during 2022 Vuzix Corporation ($VUZI) Q3 EPS loss (-$0.13), in-line with ests; Q3 revs $3.02M vs. est. $3.79M; General and Administrative expense for the three months ended September 30, 2021 was $3.1 million versus $1.6 million for the comparable 2020 period Xperi Holding Corporation ($XPER) 3Q adj EPS $0.53 vs est. $0.34 on res $219.4Mm vs est. $215.4Mm; guides FY revs $870-890Mm vs est. $882.2Mm Zynga ($ZNGA) 4Q EPS ($0.04) vs est. $0.07 on revs $704.7Mm vs est. $666Mm, qtrly bookings $668Mm +6%, average mobile DAUs 38Mm +21%, qtrly avg mobile MAUs 183Mm +120%; sees FY revs $2.78B vs est. $2.81B, sees FY bookings $2.814B

Monday, November 8, 2021 Futures Up/Down % Last Dow 72.00 0.20% 36,287 S&P 500 4.25 0.09% 4,694 Nasdaq 9.00 0.06% 16,360 U.S. futures are looking to open at new record highs (again) after Washington passed a smaller form of its highway, broadband and other infrastructure improvement spending deal this weekend, as the $1 trillion infrastructure bill passed through Congress on Friday. A very important week of economic data coming up with monthly CPI, PPI inflation data mid-week. Crypto assets rising to records ahead of the inflation reports as Bitcoin up 8% nearing $66K, Ethereum record highs up over 6% above $4,700, Litecoin tops $200, up over 5.75% as crypto assets surging again. Tech futures underperform following weakness in Tesla (TSLA) after its CEO Elon Musk on Saturday asked his 62.5 million followers on Twitter in a poll if he should sell 10% of his Tesla stock. The world’s richest person had previously said he could face a “massive” tax bill this year as he has to exercise a large number of stock options coming due next year. In Asian markets, The Nikkei Index fell -100 points to 29,507, the Shanghai Index rose 0.2% to just under 3,500, and the Hang Seng Index declined 100 points to 24,763. In Europe, the German DAX is down about -0.1% at 16,035, while the FTSE 100 is flat holding just above 7,300. Last week the S&P 500, Nasdaq and Dow notched their fifth straight weekly advances (longest streak for the S&P since Aug 2020); for the week, the S&P 500 rose 2%, the Dow added 1.42%, the Nasdaq gained 3.05% and the Russell 200o over 6%. The Nasdaq 100 (QQQ) notched its 10th winning session in a row on Friday while the S&P 500 scored another record high on Friday and booked a week of solid gains following a strong U.S. jobs report and positive data for Pfizer’s experimental pill against COVID-19, which helped boost travel and other economic reopen sectors. The news kept the run going for equities after investors earlier in the week digested the Federal Reserve’s decision to start reducing its monthly bond purchases put in place to support the economy. Market Closing Prices Yesterday The S&P 500 Index gained 17.47 points, or 0.37%, to 4,697.53 The Dow Jones Industrial Average rose 203.72 points, or 0.56%, to 36,327.95 The Nasdaq Composite climbed 31.28 points, or 0.20%, to 15,971.59 The Russell 2000 Index advanced 34.65 points, or 1.44% to 2,437.08 Events Calendar for Today No major U.S. economic data Earnings Calendar: Earnings Before the Open: ATRO, AXSM, BKI, COTY, DS, EDIT, EHTH, GATO, GTES, HLIO, KOS, LINC, NERV, NSSC, RDNT, RDUS, RETA, THS, TTD, USFD, VAC, VUZI, WOW, ZIXI Earnings After the Close: ACAD, AEIS, AEL, AMBC, AMC, AMPH, AMRS, APEI, APPF, APTS, ASUR, ATER, AVEO, BAND, BRP, CARA, CBT, CHRS, CLRS, CLOV, CSSE, CSTL, CXW, DDD, DOOR, ENV, FIVN, FLDM, FRPT, FSK, FTK, GOSS, HIL, IEA, IFF, IIN, INST, IPAR, JKHY, KERN, LMND, LOTZ, MRC, MRTX, MWA, NCMI, NEWR, NNI, NVRO, NVTA, OCIUL, OUST, PRA, PRI, PRIM, PYPL, RBLX, REAL, SANM, SCOR, SDC, SNCR, SPCE, SWSP, SWAV, SWX, TCMD, TREX, TRIP, TWO, XNCR, ZIOP, ZNGA Other Key Events: Credit Suisse 30th Annual Healthcare Conference, 11/8-11/11 (virtual) JPMorgan Global Consumer, Retail & Luxury Conference, 11/8-11/21 (virtual) EEI Financial Conference, 11/7-11/9 (virtual) REITWorld 2021 Annual Conference, 11/9-11/12 (virtual) Macro Up/Down Last Nymex 1.22 82.49 Brent 1.09 83.83 Gold -0.50 1,818.50 EUR/USD -0.0002 1.1564 JPY/USD 0.05 113.46 10-Year Note +0.032 1.485% World News China’s export growth moderated slightly to 27.1% yoy in October, above the 22.8% consensus expectation, implying a sequential gain of 2.6% in October (a modest slowdown from +3.0% in September) despite electricity constraints in October. At the same time, imports rose 20.6% yoy in October, missing expectations of a 26.2% surge, but fell 3.2% sequentially in October (vs. -0.7% in September). As a result of the far bigger growth in exports over imports, the monthly trade surplus rose further to a record high of $84.5bn in October, supporting the appreciation of the Chinese yuan in October, even as China’s economy has slowed down sharply in recent months. China’s trade surplus with the United States was $40.75 billion in October based on customs data showed on Sunday, down from $42 billion in September. For the first ten months of the year, the surplus was $320.67 billion – Reuters Highway, broadband and other infrastructure improvement spending deal this weekend, as the $1 trillion infrastructure bill passed through Congress on Friday and among parts of the deal, allows for $7.5 billion spending for building out a network of electric vehicle chargers and another $7.5 billion for low or zero-emission buses and ferries. Sector News Breakdown Consumer Tesla Inc ($TSLA) CEO Elon Musk on Saturday asked his 62.5 million followers on Twitter in a poll if he should sell 10% of his Tesla stock. The world’s richest person had previously said he could face a “massive” tax bill this year as he has to exercise a large number of stock options coming due next year. “Note, I do not take a cash salary or bonus from anywhere. I only have stock, thus the only way for me to pay taxes personally is to sell stock,” Musk said on Twitter on Saturday. Rivian Automotive ($RIVN) raises IPO price range to $72.00-$74.00 from $57.00-$62.00. Separately, Barron’s noted Rivian Automotive (RIVN) is set to go public this coming week at a market value that could exceed that of Honda Motor (HMC) despite having sold just a handful of vehicles, with a market cap around $64 billion Haverty’s (HVT) announces special cash dividend, quarterly cash dividend, and additional authorization under stock repurchase program Peloton ($PTON) has halted hiring across all departments effective immediately, CNBC reported late Friday, a day after it slashed its full-year outlook amid slowing momentum for its fitness products Coty ($COTY) agrees to sell additional partial stake in Wella to KKR in exchange for about 56% of Preferred Coty shares owned by KKR Marriott Vacations ($VAC) Q3 adjusted EPS $1.60 vs. est. $1.42; Q3 revs $1.05B vs est. $1.07B; said occupancies at our resorts this quarter were very strong despite the Delta variant and contract sales were within 3% of 2019 levels, driving 25% sequential growth in Adjusted EBITDA Energy China’s crude oil imports plunged in October to the lowest since September 2018, as large state-owned refiners withheld purchases because of rising prices while independent refiners were restrained by limited quotas to import. The world’s biggest crude oil importer brought in 37.8 million tonnes last month, data from the General Administration of Customs showed on Sunday, equivalent to 8.9 million barrels per day (bpd). – Reuters FirstEnergy ($FE) agrees to sell a 19.9% stake in its three regulated transmission businesses to Brookfield Asset Management (BAM) for $2.4B Financials Berkshire Hathaway Inc ($BRK/A) said that global supply chain disruptions kept a lid on its ability to generate profit; Q3 operating profit rose 18% but missed analyst forecasts amid goods shortages that crimped consumer spending; net income, meanwhile, fell 66%, reflecting lower gains from stock holdings such as Apple Inc and Bank of America Corp. Alleghany ($Y) mentioned positively in Barron’s saying shares should not be overlooked noting under CEO Weston Hicks, Alleghany has used a similar strategy to create an attractive, smaller-scale version of Warren Buffett’s Berkshire Hathaway ($BRK.A) R. Berkley ($WRB) announced that its Board of Directors has declared a special cash dividend on its common stock of $1.00 per share to be paid on December 22 to stockholders of record at the close of business on December 7 Healthcare Cannabis stocks rose late Friday after Marijuana Moment reported a fresh Republican-led attempt to legalize marijuana. The States Reform Act led by Rep. Nancy Mace (R-SC) is still in the preliminary stage, and a final version is expected to be filed later this month. As U.S. health authorities expand use of the leading Covid-19 vaccines, researchers investigating heart-related risks linked to the shots are exploring several emerging theories, including one centered on the spike protein made in response to vaccination. Researchers aren’t certain why the messenger RNA vaccines, one from Pfizer Inc. ($PFE) and partner BioNTech SE ($BNTX) and the other from Moderna Inc., are likely causing the inflammatory heart conditions myocarditis and pericarditis in a small number of cases. – WSJ https://on.wsj.com/3mQqCVY Alcon ($ALC) has acquired Ivantis, developer and manufacturer of the novel Hydrus Microstent, a minimally-invasive glaucoma surgery (MIGS) device designed to lower intraocular pressure for open-angle glaucoma patients in connection with cataract surgery for $475M in upfront consideration Genetron Holdings ($GTH) has formed a strategic partnership with oncology laboratory solution provider NeoGenomics (NEO) to drive global oncology drug research and development. Industrials & Materials Boeing ($BA) directors agreed to a $237.5 million settlement of claims that they turned a blind eye to safety issues related to 737 Max jetliners whose crashes have cost the company more than $20 billion, according to court documents Blade Air Mobility ($BLDE) is bringing ride-sharing to helicopters-just don’t call it the Uber ($UBER) of the sky. The stock can take off without that comparison, Barron’s reported. Blade Air Mobility is a less risky way to invest in the eVTOL future, though certainly not risk-free BHP is close to a deal to sell its controlling interest in two Australian coal mines to Stanmore Resources Ltd. ($STMRF) for ~$1.25B, the Wall Street Journal reports. Technology, Media & Telecom New Oriental Education & Technology ($EDU), Gaotu Techedu ($GOTU), and Tal Education ($TAL) shares all rising over 20% after the WSJ reported that China plans to issue more than a dozen licenses that would allow companies to offer after-school tutoring. The report said Gaotu Techedu (GOTU) and Yuanfudao, a unit of Tencent ($TCEHY), have held talks about resuming tutoring to students in the ninth grade and below https://on.mktw.net/3EVcxg5 Trinseo ($TSE) has begun work to explore the divestiture of its Styrenics businesses and plans to launch a formal sales process in Q1 of 2022. The scope of this potential divestiture is expected to include the Feedstocks and Polystyrene reporting segments as well as the company’s 50% ownership of Americas Styrenics AU Optronics ($AUOTY) reports October revenue of NT$30.38B (+18.1% Y/Y, -9.9% M/M); the total panel area shipment reached around 2.08 million square meters in October 2021, down by 4.3% month-over-month. ChipMOS ($IMOS) reports October revenue of $82.3M (-2.3% M/M; +10.7% Y/Y).

676 $MRTX NOV2021 $180 Cs trade 5.6

676 $MRTX NOV2021 $180 Cs trade 5.6

913 $MRTX JAN2022 $230 Cs trade 6.5

913 $MRTX JAN2022 $230 Cs trade 6.5

Friday, October 8, 2021 Futures Up/Down % Last Dow 42.00 0.12% 34,678 S&P 500 2.50 0.06% 4,392 Nasdaq 0.00 0.00% 14,881 After a week of overnight swings and market volatility, U.S. futures come into Friday’s trading looking flat, with the S&P little changed at 4,390 after a strong session on Thursday was met with a late day pullback, as major averages finished well off their best levels. U.S. futures steady as investors anticipate a key employment report that could offer clues on the Fed’s timeline for reducing bond purchases. Nonfarm payroll data at 8:30 AM with an est. for +500K jobs added, private payrolls est. +455K, manufacturing payrolls +25K and the unemployment rate to fall to 5.1% from 5.2%; average hourly earnings expected to rise +0.4% (vs. last month +0.6%). Equities rose and Treasuries sank on Thursday after Senate leaders pulled the U.S. from the brink of default with a deal for a short-term debt ceiling increase in the amount of $480B to a $28.9 trillion debt limit. However, this could be short lived as the agreement only funds Treasury debt until Dec. 3, meaning Senators will again face a deadline for default. In Asian markets, the Shanghai Index opened for trading after a week long pause to celebrate its Golden Week holiday, rising 24 points to 3,592, the Hang Seng Index gained 136 points to 24,837 and the Nikkei advanced 370 points (1.34%) to 28,048. In Europe, the German DAX is down a few points at 15,235, while the FTSE 100 is up a few at 7,085. Oil prices are higher, heading for its seventh weekly gain with WTI crude nearing $80 Market Closing Prices Yesterday The S&P 500 Index gained 36.21 points, or 0.83%, to 4,399.76 The Dow Jones Industrial Average rose 337.95 points, or 0.98%, to 34,754.94 The Nasdaq Composite surged 152.10 points, or 1.05%, to 14,654.02 The Russell 2000 Index advanced 35.14 points, or 1.59% to 2,250.09 Events Calendar for Today 8:30 AM ET Non-Farm Payrolls for September…est. +500K 8:30 AM ET Private Payrolls for September…est. +455K 8:30 AM ET Manufacturing Payrolls for September…est. +25K 8:30 AM ET Unemployment Rate for September…est. 5.1% 8:30 AM ET Average Hourly Earnings for September…est. +0.4% 10:00 AM ET Wholesale Inventories MoM for Aug 1:00 PM EST Baker Hughes Weekly rig count data Macro Up/Down Last Nymex 0.58 78.86 Brent 0.65 82.60 Gold 0.90 1,762.00 EUR/USD 0.0014 1.1563 JPY/USD 0.23 111.82 10-Year Note +0.021 1.593% World News The U.S. Senate on Thursday approved legislation to temporarily raise the federal government’s $28.4 trillion debt limit and avoid the risk of a historic default this month, but it put off until early December a decision on a longer-lasting remedy. German Aug Trade Balance smaller surplus: +€13.0b vs +€15.8b consensus; German August Exports lower down -1.2% vs +0.5% consensus and German Aug Imports higher rising +3.5% vs 1.8% consensus Sector News Breakdown Consumer Home Depot ($HD) and Lowe’s ($LOW) both downgraded to Hold from Buy at Loop Capital Tesla ($TSLA) CEO Elon Musk confirmed that the car maker is moving its headquarters from Fremont, California to Austin, Texas, where the company has been constructing a new factory for a little over a year. CEO Musk also said a global shortage of chips and ships is the only thing standing in the way of the company maintaining sales growth in excess of 50% Oatly Group ($OTLY) upgraded to Overweight from Neutral with a $21 price target Drive Shack ($DS) reports prelim Q3 revs of $75M vs. est. $76.74M Scientific Games ($SGMS) wins 10-year Vermont lottery systems contract; company’s advanced platforms and game services will modernize lottery play and maximize revenues for programs in green mountain state Thor Industries ($THO) increases regular quarterly dividend 5% to 43c per share Energy, Industrials and Materials Dow Transports finished the day down -0.25% just above the 14,500 level, but slipping below its 50-day MA at 14,515 B. Hunt ($JBHT) downgraded to Underweight on relative valuation at JPMorgan Union Pacific ($UNP) upgraded to Overweight from Neutral with a price target of $247, up from $234 at JPMorgan on recent selloff Sundial Growers Inc. ($SNDL) announced it will acquire liquor and pot retailer Alcanna in an all-stock deal with a total consideration of about C$346M Financials Pzena Investment Management Inc. ($PZN) prelim AUM as of Sept 30 of $50.8 bln Chubb ($CB) announced a definitive agreement to acquire the life and non-life insurance companies that house the personal accident, supplemental health and life insurance business of Cigna (CI) in seven Asia-Pacific, or APAC, markets for $5.75B in cash Healthcare Accolade Inc. ($ACCD) Q2 revs $73.3M vs. est. $70.4M; Q2 adj Ebitda loss (-$19.4M) vs. est. loss (-$21.9m); sees FY revs $303M-$307M, from prior view $300M-$305M (est. $303.4M); guides Q3 adj Ebitda loss $21.5M-$24.5M vs. est. loss $20.2M, but Q3 revs above views Quidel ($QDEL) guides Q3 revs $505M-$510M vs. est. $186.3M; says covid-19 revenues for Q3 of 2021 expected to be about $406M, compared with $375.7M YoY Allogene Therapeutics ($ALLO) shares fall over 35% after reporting the FDA put a clinical hold of Allocar T trials based on a single patient case in alpha2 trial; believes data from alpha trials demonstrates a favorable clinical profile of allo-501a Apollo EndoSurgery ($APEN) sees 3Q revs $16-16.4Mm vs est. $14.4Mm; sees 3Q net loss $6.1-7.3Mm vs est. net loss $8.3Mm BeiGene’s ($BGNE) BRUKINSA (zanubrutinib) has been approved in Australia for the treatment of adult patients with Waldenström’s macroglobulinemia who have received at least one prior therapy or in first line treatment for patients unsuitable for chemo-immunotherapy. Mirati Therapeutics ($MRTX) to collaborate with Sanofi ($SNY) on phase 1/2 study evaluating combination of adagrasib with a SHP2 inhibitor in KRAS g12c-mutated lung cancer Nkarta ($NKTX) provided updates on its NKX019 and NKX101 clinical development programs saying patients have been dosed in the international phase 1 trial of NKX019 in advanced B-cell malignancies IsoPlexis (ISO)333M share IPO priced at $15.00 Pyxis Oncology ($PYXS)5M share IPO priced at $16.00 Prelude Therapeutics ($PRLD) shares fall after announces presentation of encouraging data from multiple programs at the AACR-NCI-EORTC virtual international conference on molecular targets and cancer therapeutics Relay Therapeutics ($RLAY) announces interim clinical data for RLY-4008, in a first-in-human trial in patients with FGFR2-altered cholangiocarcinoma and multiple other solid tumors Technology, Media & Telecom VMware ($VMW) authorized new stock buyback program for up to $2B Samsung Electronics Co Ltd ($SSNLF) said Q3 operating profit likely jumped 28% to its highest in three years, helped by rising memory chip prices and brisk sales of its new foldable smartphones; estimated July-September profit at 15.8 trillion won ($13.3 billion) vs. est. of 16.1 trillion won. ChipMOS (IMOS) reports Q3 revenues rose 25.9% on a Y/Y basis to $257.2M (+2.6% Q/Q) vs. a consensus of $262.90M. Taiwan Semiconductor Manufacturing Co.’s ($TSM) September revenue was up 19.7% Y/Y to NT$152.69B or about $5.44B. AU Optronics ($AUOTY) reports September revenue rose 26.5% Y/Y to NT$33.0B (+0.9% M/M); Q3 revenues rose 35.3% Y/Y NT$99.05B Oracle ($ORCL), Telecom Italia, and Noovle, TIM Group’s cloud company, have signed a collaboration agreement to offer multi-cloud services for enterprises and the public sector organizations in Italy. Sirius XM ($SIRI) downgraded to Neutral from Overweight with a price target of $7, down from $8 at JPMorgan

$AFRM + $TGT Sezzle P-Ships $ELAN + Starboard $HUN + Starboard $ARCT, $MRTX + $MRK targets $MRVL + Guidance $M + Jana calls E-Commerce spin

+Initiations 9/23: $ANXX $AOSL $AVDL $AVXL $BIIB $BTBT $DNMR $FSR $GTLS $HRMY $ITCI $JAZZ $JOBY $KNTE $LABP $LIDR $MCG $MRTX $OVV $OXLC $PCT $RBC $RPD $RPTX $SAGE $SFET $SITC $SWBK $UE $XFLT . -Initiations 9/23: $TSLA

Thursday, September 23, 2021 Futures Up/Down % Last Dow 162.00 0.47% 34,291 S&P 500 23.25 0.53% 4,407 Nasdaq 83.50 0.55% 15,247 U.S. stocks are looking at another move higher following strong gains on Wednesday despite the FOMC taking a more “hawkish” stance on both rates and the timeline on asset purchase tapering during yesterday’s meeting. Stocks jumped on Wednesday after the Federal Reserve cleared the way to ease monthly bond purchases “soon” and signaled interest rate increases may follow more quickly than expected. Stocks pared gains late as Fed Chair Jerome Powell spoke at his press conference but still closed up solidly. Fed officials indicated that they see interest rates seen rising to 1% in 2023, faster than projected by the Fed in its projections in June, and then to 1.8% in 2024. Nine of eleven major S&P 500 sectors ended the day higher. However, of note, all 11 groups retreated from the moments before Powell’s press conference began, into the close. The Dow Transport index slid to 6-month lows following weakness from Fed-Ex (FDX) earnings results and guidance the night prior. In Asian markets, The Nikkei Index was closed, the Shanghai Index rose 13 points to 3,642 and the Hang Seng Index gained 289 points to 24,510. In Europe, the German DAX is up over 130 points (0.89%) to 15,645, while the FTSE 100 rises about 20-points to move above 7,100. Oil prices are slipping but still holds near two-month high with global stockpiles tightening. In China news, the WSJ reported China is preparing for the “demise” of Evergrande, signaling Beijing’s reluctance to get involved and bail out the company. Events Calendar for Today 8:30 AM ET Weekly Jobless Claims…est. 320K 8:30 AM EST Continuing Claims…est. 2.65M 9:45 AM ET Markit Manufacturing PMI, Sept-F…est. 61.5 9:45 AM ET Markit Services PMI, Sept-F…est. 55.0 9:45 AM ET Markit Composite PMI-Sept-F 10:00 AM ET Leading Index MoM for Aug…est. +0.7% 10:30 AM ET Weekly EIA Natural Gas Inventory Data 11:00 AM ET Kansas City Fed Manufacturing for Sept…prior 22 Earnings Calendar: Earnings Before the Open: DRI, DYNT, IWSY, RAD Earnings After the Close: AEHR, AGTC, AIR, CAMP, $COST, MTN, $NKE, PRGS, $RSSS Other Key Events: Credit Suisse 7th Annual Oil & Gas Non-Bus Tour (virtual), 9/21-9/23 DA Davidson Diversified Industrials & Services Conference (virtual), 9/22-9/23 Goldman Sachs 30th Annual Communacopia Conference (virtual), 9/21-9/23 JPMorgan 12th Annual U.S. All Stars Conference (virtual), 9/21-9/23 Oppenheimer Fall Healthcare Life Sciences & MedTech Summit (virtual), 9/20-9/23 Roth Capital 8th Annual Solar Symposium (virtual), 9/20-9/23 Sidoti Fall Small Cap Conference (virtual), 9/22-9/23 Wells Fargo 4th Annual Consumer Conference (virtual), 9/22-9/23 Market Closing Prices Yesterday The S&P 500 Index gained 41.45 points, or 0.95%, to 4,395.64 The Dow Jones Industrial Average rose 338.48 points, or 1.00%, to 34,258.32 The Nasdaq Composite jumped 150.45 points, or 1.02%, to 14896.85 The Russell 2000 Index advanced 32.38 points, or 1.48% to 2,218.56 Macro Up/Down Last Nymex -0.32 71.91 Brent -0.27 75.92 Gold 3.80 1,772.00 EUR/USD 0.0028 1.1715 JPY/USD 0.11 109.89 10-Year Note +0.003 1.335% World News China is preparing for the “demise” of Evergrande, signaling Beijing’s reluctance to get involved and bail out the company (the gov’t will only step in should the company’s failure turn disorderly) – WSJ https://on.wsj.com/3i2x8WH Sector News Breakdown Consumer Steelcase ($SCS) 2Q EPS $0.21 vs est. $0.23 on revs $724.8Mm vs est. $761.3Mm; guides 3Q revs $755-785Mm vs est. $713Mm, sees 3Q EPS $0.07-0.11 vs est. $0.09 Funko ($FNKO) entered into a new credit agreement for a term loan facility of $180M and a revolving credit facility of $100M that mature September 17, 2026 Brilliant Earth ($BRLT)33M share IPO priced at $12.00 Hyatt ($H) 7M share Secondary priced at $74.50 Sovos Brands ($SOVO)3M share IPO priced at $12.00 Energy, Industrials & Materials HB Fuller (FUL) 3Q adj EPS $0.79 vs est. $0.79 on revs $827Mm vs est. $797.6Mm; guides FY revs +17-18% vs est. +14.4%, sees FY adj EBITDA abut $460-470Mm vs est. $463Mm KB Homes (KBH) 3Q EPS $1.60 vs est. $1.62 on revs $1.47B vs est. $1.57B; qtrly homes delivered +35% to $3,425, ending backlog value +89% to $4.84B; inventory +19% to $4.66B as of Aug. 31; repurchased 4.7Mm shares for $188.2Mm Northrop Grumman ($NOC) upgraded to Neutral from Sell at Goldman Sachs with a $350 price target and General Dynamics (GD) also upgraded to Neutral from Sell at Goldman Sachs with a $176 price target in the defense sector; L3Harris Technologies (LHX) downgraded to Sell from Neutral at Goldman Sachs with a $207 price target, Lockheed Martin (LMT) downgraded to Neutral from Buy with $402 tgt and Woodward ($WWD) downgraded to Sell from Neutral with $102 tgt Loop Capital started Regal Beloit Corp (RBC) with a Buy rating and $180 price target and Timken (TKR) with a Hold rating and $72 price target Grinrod Shipping ($GRIN)842M share Spot Secondary priced at $13.50 Syncrude Canada, majority-owned by Suncor Energy ($SU), cut September supplies due to a mechanical disruption at its Alberta oil sands site, Bloomberg reported Financials Chinese Estates (Holdings) Ltd. is planning to sell all of its shares in China Evergrande Group, as the property investment company is worried about the recent stock-price volatility and financial condition of debt-laden Evergrande. Chinese Estates, which currently holds 751.09 million shares or a 5.66% stake in Evergrande, expects to record a realized loss on the stake of about 1.38 billion Hong Kong dollars ($177.2 million) for the year ending December Remitly Global (RELY)16M share IPO priced at $43.00 The9 ($NCTY), Polygon, an Ethereum scaling platform, and Protocol Labs, a major contributor of open-source projects are forming an ecosystem collaboration on NCTY’s Non-Fungible Token (NFT) platform NFTSTAR and GameFi Play-to-Earn projects Safehold (S$AFE)2M share Secondary priced at $76.00 Willis Towers Watson ($WLTW) raises share buyback program by $4B Raymond James Financials ($RJF) posts Private Client Group assets in fee-based accounts of $643.5B grew 33% Y/Y, thanks to the net addition of financial advisers; record client assets under administration of $1.21T rose from $945.2B in the year ago period and $1.18T in the prior month. Healthcare The FDA has granted Emergency Use Authorization for a booster dose of Pfizer ($PFE)/BioNTech’s ($BNTX) COVID-19 vaccine for those 65 and older, those who work in healthcare settings, and adults at high risk of severe COVID-19. The authorization includes people whose “frequent institutional or occupational exposure to SARS-CoV-2 puts them at high risk of serious complications of COVID-19.” Sterling Check (STER)285M share IPO priced at $23.00 Eargo, Inc. (EAR) shares fell -50% on reports it is the target of a criminal investigation by U.S. DOJ related to insurance reimbursement claims submitted on behalf of customers covered by federal employee health plans; the co is withdrawing its financial guidance for fiscal year ending December 31, 2021 Spectrum Pharma (SPPI) Journal of Clinical Oncology Abstract listing for co.’s ‘poziotinib for patients with HER2 exon 20 mutant non–small-cell lung cancer Cigna Corp (CI) named Eric Palmer as president and chief executive officer of Evernorth, its health services unit that mainly houses its pharmacy benefit management business; also announced several other leadership changes Medirom Healthcare (MRM) rises 39%; after saying that it will buy Japanese private hair salon operator Zacc Kabushiki Kaisha in an all-cash deal of 370.0 mln yen ($3.36M) Thorne HealthTech (THRN) 7M share IPO priced at $10.00 Stifel initiated Buy ratings on Mirati Therapeutics (MRTX) with a $202 price target, Kinnate Biopharma (KNTE) with a $32 price target, and Repare Therapeutics (RPTX) with a $48 price target; Hold ratings on Ideaya Biosciences (IDYA) and Revolution Medicines (RVMD) Needham started SAGE Therapeutics (SAGE) at a Buy and added it to its Conviction List; also initiated Buy ratings on Intra-Cellular Therapeutics (ITCI), Avadel Pharmaceuticals (AVDL), Jazz Pharmaceuticals ($JAZZ), Biogen ($BIIB), Harmony Biosciences ($HRMY), and Hold ratings on Neurocrine Biosciences ($NBIX) and ACADIA Pharmaceuticals (ACAD) Technology, Media & Telecom Blackberry ($BB) shares rose 8% after earnings; Q2 EPS ($0.06) vs est. ($0.07) on revenue $175M vs est. $163.5M Facebook ($FB) chief technology officer Mike Schroepfer said in a Facebook post: “After 13 amazing years at Facebook, I have made the decision to step down as Chief Technology Officer and transition to a new part time role as Facebook’s first Senior Fellow at the company sometime in 2022 EngageSmart ($ESMT)55M share IPO priced at $26.00 Roku ($ROKU) upgraded to Buy from Neutral at Guggenheim

2000 $MRTX Jan 2022 210 Calls trade $6.60 (Cboe Theo=5.54) ASKSIDE PHLX IV=54.0% +2.8 FLOOR - OPENING Vol=2000, OI=70,

1000 $MRTX DEC2021 $180 Cs trade 17.7

1000 $MRTX DEC2021 $180 Cs trade 17.7

stalking LAC, IIPR, CDIQ, NET, MRTX

Downgrades 11/10: $BCS $BK $BLDP $CHMI $CIT $CPT $FMBI $FSLR $HA $HFC $INBK $LMRK $MRTX $MS $NOV $PDCO $RES $RL $SLRC $SNV $SSTI $VYGR $WHD